According to a detective, the incident began as a home invasion at the 7000 block of Sherman.
Authorities say the homeowner defended himself when the suspects entered the home. Following the shooting, the suspects fled from the scene.
ABC13 Exclusive interview with witness
Exclusive interview with witness who heard home invasion shooting
Police have set up a perimeter stretching from Harrisburg to Sherman to Capitol, along 71st Street.
At another scene, a vehicle was found about two blocks from the shooting, where a man was found dead in the backseat.
Authorities say that out of five people shot, three of them died.
A witness at the scene says he went outside when he heard the shots to make sure he wasn't dreaming.
Homeowner opens fire on suspected home invaders
In the exclusive interview, the man added he saw two other guys in the front of the home, on the ground.
"I heard around five or six gunshots. I'm pretty sure there were more before that," he said.
At some point, officers with guns drawn were seen searching a port-a-potty.
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